A Rigorous Sharp Interface Limit of a Diffuse Interface Model Related to Tumor Growth

نویسندگان

  • Elisabetta Rocca
  • Riccardo Scala
چکیده

In this paper we study the rigorous sharp interface limit of a diffuse interface model related to the dynamics of tumor growth, when a parameter ε, representing the interface thickness between the tumorous and non tumorous cells, tends to zero. More in particular, we analyze here a gradient-flow type model arising from a modification of the recently introduced model for tumor growth dynamics in [21] (cf. also [22]). Exploiting the techniques related to both gradient-flows and gamma convergence, we recover a condition on the interface Γ relating the chemical and double-well potentials, the mean curvature, and the normal velocity.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A preconditioned solver for sharp resolution of multiphase flows at all Mach numbers

A preconditioned five-equation two-phase model coupled with an interface sharpening technique is introduced for simulation of a wide range of multiphase flows with both high and low Mach regimes. Harten-Lax-van Leer-Contact (HLLC) Riemann solver is implemented for solving the discretized equations while tangent of hyperbola for interface capturing (THINC) interface sharpening method is applied ...

متن کامل

A sharp-interface interpretation of a continuous density model for homogenization of gravity-driven flow in porous media

We examine homogenization methods applied to sharp-interface and diffuse-interface models for gravity-driven flow in heterogeneous porous media. Our work specifically examines a matrix of models that includes (1) a variable media, diffuse-interface model, (2) a variable media, sharp-interface model, (3) a homogenized media, diffuse-interface model and (4) a homogenized media, sharp-interface mo...

متن کامل

Three-dimensional multispecies nonlinear tumor growth--I Model and numerical method.

This is the first paper in a two-part series in which we develop, analyze, and simulate a diffuse interface continuum model of multispecies tumor growth and tumor-induced angiogenesis in two and three dimensions. Three-dimensional simulations of nonlinear tumor growth and neovascularization using this diffuse interface model were recently presented in Frieboes et al. [2007. Computer simulation ...

متن کامل

On sharp interface limits for diffuse interface models for two-phase flows

We discuss the sharp interface limit of a diffuse interface model for a two-phase flow of two partly miscible viscous Newtonian fluids of different densities, when a certain parameter " > 0 related to the interface thickness tends to zero. In the case that the mobility stays positive or tends to zero slower than linearly in "we will prove that weak solutions tend to varifold solutions of a corr...

متن کامل

Three-Dimensional Diffuse-Interface Simulation of Multispecies Tumor Growth–I: Numerical Method

We present a tumor-level diffuse interface model of cancer growth. This work expands the capability to simulate non-symmetric, multispecies tumor growth at the continuum level in three spatial dimensions, enabling more detailed description of disease progression and treatment. Specifically, we use a Cahn-Hilliard-type equation with added advection and reaction terms to describe tumor growth and...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • J. Nonlinear Science

دوره 27  شماره 

صفحات  -

تاریخ انتشار 2017